Normalization in quantitative [18F]FDG PET imaging: the 'body surface area' may be a volume

Phys Med Biol. 2006 Feb 7;51(3):N47-50. doi: 10.1088/0031-9155/51/3/N03. Epub 2006 Jan 19.

Abstract

Non-invasive methods for quantifying [(18)F]FDG uptake in tumours often require normalization to either body weight or body surface area (BSA), as a surrogate for [(18)F]FDG distribution volume (DV). Whereas three dimensions are involved in DV and weight (assuming that weight is proportional to volume), only two dimensions are obviously involved in BSA. However, a fractal geometry interpretation, related to an allometric scaling, suggests that the so-called 'body surface area' may stand for DV.

MeSH terms

  • Biophysical Phenomena
  • Biophysics
  • Body Surface Area
  • Body Weight
  • Fluorodeoxyglucose F18 / chemistry*
  • Fractals
  • Humans
  • Models, Theoretical
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / pharmacology

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18