New approaches to combating antimicrobial drug resistance

Genome Biol. 2005;6(13):243. doi: 10.1186/gb-2005-6-13-243. Epub 2005 Dec 23.

Abstract

Recent work shows that the inhibition of the SOS stress response in Escherichia coli reduces the development of resistance to the antibiotics ciprofloxacin and rifampicin. This finding may help in the battle against the rise of resistance to antimicrobial drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial / drug effects*
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli / physiology*
  • Models, Biological
  • Mutation / genetics
  • SOS Response, Genetics / drug effects*

Substances

  • Anti-Bacterial Agents