Abstract
A new series of 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives bearing 2-chloroethylamine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base (after condensation with 2-chloroethylamine) units and having also 2-naphthyl or anthraquinone groups as cosubstituents has been synthesized. The in vitro cytotoxic activity of these compounds against a panel of four cancer cell lines has been studied. Most of the compounds exhibited antiproliferative activity in the range of the international criterion for synthetic agents (4 microg/mL) against the MOLT4, L 1210, HL-60, and P388 cell lines chosen for testing.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aldehydes / chemical synthesis
-
Aldehydes / chemistry
-
Aldehydes / pharmacology
-
Animals
-
Anthraquinones / chemical synthesis
-
Anthraquinones / chemistry
-
Anthraquinones / pharmacology
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
-
Bridged Bicyclo Compounds, Heterocyclic / chemistry
-
Bridged Bicyclo Compounds, Heterocyclic / pharmacology
-
Cell Line, Tumor
-
Crown Ethers / chemical synthesis
-
Crown Ethers / chemistry
-
Crown Ethers / pharmacology
-
Drug Screening Assays, Antitumor
-
Humans
-
Intercalating Agents / chemical synthesis
-
Intercalating Agents / chemistry
-
Intercalating Agents / pharmacology
-
Leukemia
-
Mice
-
Naphthalenes / chemical synthesis
-
Naphthalenes / chemistry
-
Naphthalenes / pharmacology
-
Organophosphorus Compounds / chemical synthesis*
-
Organophosphorus Compounds / chemistry
-
Organophosphorus Compounds / pharmacology
-
Structure-Activity Relationship
Substances
-
Aldehydes
-
Anthraquinones
-
Antineoplastic Agents
-
Bridged Bicyclo Compounds, Heterocyclic
-
Crown Ethers
-
Intercalating Agents
-
Naphthalenes
-
Organophosphorus Compounds
-
salicylaldehyde