Abstract
Schiff base conjugates of p-aminosalicylic acid have been synthesized and characterized by elemental analysis, IR and (1)H NMR spectroscopy and cyclic voltammetry. Compounds containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher ClogP values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminosalicylic Acid / chemical synthesis
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Aminosalicylic Acid / chemistry
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Aminosalicylic Acid / pharmacology*
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Mycobacterium bovis / drug effects*
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Mycobacterium smegmatis / drug effects*
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Schiff Bases / chemistry*
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Free Radical Scavengers
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Schiff Bases
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Aminosalicylic Acid