Abstract
A novel test for the identification of genes involved in aldehyde metabolism is proposed, based on detection of altered sensitivity of the yeast to corresponding alcohols, metabolic precursors of the aldehydes. This attitude enabled to an unexpected detection increased sensitivity of mutants devoid of CuZn-superoxide dismutase (CuZnSOD) to allyl alcohol (precursor of acrolein) and nonenol. We interpret this finding as due to inactivation of some important element of aldehyde detoxification by increased flux of superoxide in DeltaCuZnSOD mutants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrolein / pharmacology
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Aldehydes / metabolism*
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Aldehydes / pharmacology*
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Glutathione / physiology
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Inactivation, Metabolic
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Mutation
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Propanols / pharmacology
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Saccharomyces cerevisiae / drug effects*
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / metabolism
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Superoxide Dismutase / genetics
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Superoxide Dismutase / physiology
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Superoxide Dismutase-1
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Superoxides / metabolism*
Substances
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Aldehydes
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Propanols
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Superoxides
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allyl alcohol
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Acrolein
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Superoxide Dismutase
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Superoxide Dismutase-1
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Glutathione