Abstract
Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A(2) and A(4) showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acenaphthenes / chemical synthesis*
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Acenaphthenes / chemistry
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Acenaphthenes / pharmacology*
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Animals
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Biomarkers, Tumor
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Cell Hypoxia / drug effects*
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Cells, Cultured / drug effects
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Cricetinae
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / chemistry
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Cyclopentanes / pharmacology*
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Drug Design
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / pharmacology*
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Nitriles / chemical synthesis*
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Nitriles / chemistry
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Nitriles / pharmacology*
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Oxygen / metabolism
Substances
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Acenaphthenes
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Biomarkers, Tumor
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Cyclopentanes
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Fluorescent Dyes
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Nitriles
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Oxygen