Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

Yuanqiang Guo; Jing Xu; Yushan Li; Ryuichi Watanabe; Yasukatsu Oshima; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1248/cpb.54.123

Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

Chem Pharm Bull (Tokyo). 2006 Jan;54(1):123-5. doi: 10.1248/cpb.54.123.

Authors

Yuanqiang Guo¹, Jing Xu, Yushan Li, Ryuichi Watanabe, Yasukatsu Oshima, Tohru Yamakuni, Yasushi Ohizumi

Affiliation

¹ Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

PMID: 16394565
DOI: 10.1248/cpb.54.123

Abstract

A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Iridoids / chemistry*
Iridoids / pharmacology*
Magnetic Resonance Spectroscopy
Nerve Growth Factors / chemistry*
Neurites / drug effects
PC12 Cells
Plant Roots / chemistry
Rats
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology*
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Fast Atom Bombardment
Valerian / chemistry*

Substances

Iridoids
Nerve Growth Factors
Sesquiterpenes