Abstract
From the hydromethanolic extract of the aerial parts of Globularia alypum grown in Morocco, a new chlorinated iridoid glucoside, globularioside has been isolated beside 5 known iridoid glycosides, globularin, globularicisin, globularidin, globularinin and globularimin. This is the first report of a chlorinated iridoid in G. alypum and in the Globulareaceae. Unlike all other known 7-chlorinated iridoid glucosides where the chlorine atom exhibits an alpha configuration, globularioside incorporate the chlorine atom as a 7beta substituent. The structures of the isolated compounds were established on the basis of ESI-MS, MS-MS, 1D and 2D NMR spectral analysis.
MeSH terms
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Biphenyl Compounds
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Carbohydrate Sequence
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Chromatography, Liquid
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Free Radicals / chemistry
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Iridoids / chemistry*
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Iridoids / isolation & purification
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Iridoids / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Sequence Data
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Picrates / chemistry
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Scrophulariaceae / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
Substances
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Antioxidants
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Biphenyl Compounds
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Free Radicals
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Glucosides
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Iridoids
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Picrates
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Plant Extracts
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1,1-diphenyl-2-picrylhydrazyl