Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico

Guadalupe Hernández-Pacheco; Luis Enrique Murguía; José Manuel Rodríguez-Pérez; José Manuel Fragoso; Nadia Pérez-Vielma; Nancy Martínez-Rodríguez; Julio Granados; Gilberto Vargas-Alarcón

Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico

Hum Biol. 2005 Jun;77(3):385-91.

Authors

Guadalupe Hernández-Pacheco¹, Luis Enrique Murguía, José Manuel Rodríguez-Pérez, José Manuel Fragoso, Nadia Pérez-Vielma, Nancy Martínez-Rodríguez, Julio Granados, Gilberto Vargas-Alarcón

Affiliation

¹ Department of Physiology and Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiología "Ignacio Chávez," Juan Badiano No. 1, Tlalpan 14080, Mexico City, Mexico.

PMID: 16392639

Abstract

Matrix gamma-carboxyglutamic acid protein (MGP) genotypes (G-7A and T-138C) were determined in 266 individuals from three Mexican populations. Mexicans showed increased frequencies of the G-7A G allele and the G7-A GG genotype compared to Europeans. For the T-138C genotype, we found differences among the Mexicans. This study could help to define the significance of MGP polymorphisms as genetic markers in Amerindian populations.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Calcium-Binding Proteins / genetics*
Extracellular Matrix Proteins / genetics*
Gene Frequency
Genetic Markers
Genotype
Humans
Indians, North American / genetics*
Matrix Gla Protein
Mexico
Polymorphism, Genetic*
Promoter Regions, Genetic
White People / genetics*

Substances

Calcium-Binding Proteins
Extracellular Matrix Proteins
Genetic Markers