Abstract
By analyzing the colonization of the anterior nares in cardiothoracic surgery patients on admission, nasal cocolonization by methicillin-susceptible Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci was detected in 8/235 (3.4%) specimens. Consequently, in a low-methicillin-resistant S. aureus (MRSA) setting, a molecular MRSA screening test targeting the mecA gene and an S. aureus-specific gene in parallel and applied directly to clinical specimens would be associated with an unacceptable positive predictive value of about 40%.
MeSH terms
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Bacterial Proteins
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Coagulase / metabolism*
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False Positive Reactions
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Humans
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Methicillin / pharmacology*
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Methicillin Resistance / genetics*
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Nose / microbiology*
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Penicillin-Binding Proteins
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Predictive Value of Tests
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Staphylococcal Infections / diagnosis*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / enzymology
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Staphylococcus aureus / genetics
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Staphylococcus aureus / isolation & purification
Substances
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Bacterial Proteins
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Coagulase
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Penicillin-Binding Proteins
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mecA protein, Staphylococcus aureus
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Methicillin