A unimolecular G-quadruplex that functions as a synthetic transmembrane Na+ transporter

J Am Chem Soc. 2006 Jan 11;128(1):38-9. doi: 10.1021/ja056888e.

Abstract

We describe the covalent post-modification of a hydrogen-bonded assembly with the subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting unimolecular G-quadruplex folds in the environment of a phospholipid membrane and functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport assays.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cations, Monovalent
  • Circular Dichroism
  • DNA / chemistry*
  • DNA / metabolism
  • G-Quadruplexes
  • Guanine / analogs & derivatives*
  • Guanine / metabolism
  • Ion Transport
  • Lipid Bilayers / chemistry
  • Lipid Bilayers / metabolism
  • Membranes, Artificial
  • Nuclear Magnetic Resonance, Biomolecular
  • Sodium / chemistry*
  • Sodium / metabolism

Substances

  • Cations, Monovalent
  • Lipid Bilayers
  • Membranes, Artificial
  • Guanine
  • DNA
  • Sodium