The authors submit information on the course and therapeutic experience with acyclovir (Zovirax Wellcome Co. and Herpesin Lachema Co.) in 67 children with eczema herpeticatum (EH) who were hospitalized at the Clinic of Infectious Child Diseases in Brno from January 1983 to January 1991. In all instances treatment led to rapid drying of the herpetis eruptions, a shorter period of new eruption and rapid improvement of the serious clinical condition. In none of the children visceral dissemination of the virus of herpes simplex (HSV) were occurred and in none of the children toxic side-effects were found. The authors confirmed the assumed identical course of EH after i. v. administration of acyclovir of foreign or local origin. After i.v. administration frequently dramatic improvement of the general and local finding was recorded, as compared with oral administration. There were no therapeutic differences in the clinical effects of tablets and suspension, the clinical effect being comparable.