Application of RCM reaction in the construction of ABC ring of micrandilactone A

Yan-Dong Zhang; Ye-Feng Tang; Tuo-Ping Luo; Juan Shen; Ji-Hua Chen; Zhen Yang

doi:10.1021/ol052630h

Application of RCM reaction in the construction of ABC ring of micrandilactone A

Org Lett. 2006 Jan 5;8(1):107-10. doi: 10.1021/ol052630h.

Authors

Yan-Dong Zhang¹, Ye-Feng Tang, Tuo-Ping Luo, Juan Shen, Ji-Hua Chen, Zhen Yang

Affiliation

¹ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Shenzhen Graduate School, Peking University, Beijing.

PMID: 16381579
DOI: 10.1021/ol052630h

Abstract

[reaction: see text] The functionalized ABC ring system of micrandilactone A was successfully constructed in 14 steps. The key reactions in this synthesis are the intermolecular Diels-Alder reaction (IMDA) and the eneyne ring-closing metathesis (RCM) reaction.