Abstract
One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gammadelta-TcR+ T cells and alphabeta-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmune Diseases / immunology
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Autoimmune Diseases / pathology
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Graft Rejection / immunology
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Graft Rejection / pathology
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Humans
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Immunity, Cellular*
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / metabolism*
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NK Cell Lectin-Like Receptor Subfamily K / chemistry
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NK Cell Lectin-Like Receptor Subfamily K / physiology*
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Neoplasms / immunology
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Neoplasms / pathology
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism*
Substances
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NK Cell Lectin-Like Receptor Subfamily K