Dichlorinated pulvinic acid derivative from a Malaysian Scleroderma sp

Sonia A van der Sar; John W Blunt; Anthony L J Cole; Laily B Din; Murray H G Munro

doi:10.1021/np0503395

Dichlorinated pulvinic acid derivative from a Malaysian Scleroderma sp

J Nat Prod. 2005 Dec;68(12):1799-801. doi: 10.1021/np0503395.

Authors

Sonia A van der Sar¹, John W Blunt, Anthony L J Cole, Laily B Din, Murray H G Munro

Affiliation

¹ Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.

PMID: 16378381
DOI: 10.1021/np0503395

Abstract

A new dichlorinated pulvinic acid derivative, methyl-3',5'-dichloro-4,4'-di-O-methylatromentate, was isolated from the fruiting body of a Scleroderma sp. The structure was determined using spectroscopic methods, and an X-ray analysis was carried out for confirmation of the structure. Compound was found to display moderate antimicrobial activity against Bacillus subtilis.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Bacillus subtilis / drug effects*
Carboxylic Acids / chemistry
Carboxylic Acids / isolation & purification*
Carboxylic Acids / pharmacology
Crystallography, X-Ray
Fruiting Bodies, Fungal / chemistry*
Lactones / chemistry
Lactones / isolation & purification*
Lactones / pharmacology
Malaysia
Microbial Sensitivity Tests
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Anti-Bacterial Agents
Carboxylic Acids
Lactones
methyl-3',5'-dichloro-4,4'-di-O-methylatromentate