Effects of morning versus evening intake of atorvastatin on major cardiac event and restenosis rates in patients undergoing first elective percutaneous coronary intervention

Am J Cardiol. 2006 Jan 1;97(1):44-7. doi: 10.1016/j.amjcard.2005.07.107. Epub 2005 Nov 8.

Abstract

It is not known whether taking atorvastatin in the morning versus in the evening has a different effect on major cardiac event and restenosis rates in patients undergoing percutaneous coronary intervention. Therefore, the aim of the present study was to investigate the effects of morning versus evening intake of atorvastatin on major cardiac events and restenosis rates and also on serum lipid and high sensitivity C-reactive protein levels in patients with single-vessel disease who underwent first elective percutaneous coronary intervention.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Angina Pectoris / epidemiology
  • Angioplasty, Balloon, Coronary*
  • Atorvastatin
  • C-Reactive Protein / analysis
  • Chronotherapy*
  • Coronary Restenosis / epidemiology
  • Coronary Restenosis / prevention & control*
  • Coronary Stenosis / therapy
  • Female
  • Heptanoic Acids / administration & dosage*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
  • Lipids / blood
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Prospective Studies
  • Pyrroles / administration & dosage*
  • Treatment Outcome

Substances

  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Lipids
  • Pyrroles
  • C-Reactive Protein
  • Atorvastatin