CyNodal, the Japanese newt nodal-related gene, is expressed in the left side of the lateral plate mesoderm and diencephalon

Gene Expr Patterns. 2006 Mar;6(3):294-8. doi: 10.1016/j.modgep.2005.07.008. Epub 2005 Dec 27.

Abstract

The nodal and nodal-related genes play fundamental roles during deuterostome left-right axis formation. Several of these genes show left-sided expression in the lateral plate mesoderm and brain region. We have isolated the nodal-related gene, CyNodal, from Cynops pyrrhogaster. CyNodal mRNA is detected at the marginal zone and left side of several tissues. The left-sideness of CyNodal mRNA expression is highly conserved throughout vertebrate evolution. However, CyNodal mRNA expression shows little variation from the Xenopus nodal-related gene 1, in that CyNodal gene expression in the left lateral plate mesoderm shifts from posterior to anterior at least twice.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Body Patterning / genetics*
  • Body Patterning / physiology
  • Conserved Sequence
  • Cysteine / chemistry
  • DNA, Complementary / genetics
  • DNA, Complementary / isolation & purification
  • Diencephalon / metabolism*
  • Embryo, Nonmammalian
  • Evolution, Molecular
  • Female
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Mesoderm / metabolism*
  • Molecular Sequence Data
  • Proteins / genetics*
  • Salamandridae* / embryology
  • Salamandridae* / genetics
  • Salamandridae* / metabolism
  • Sequence Homology, Amino Acid
  • Staining and Labeling

Substances

  • DNA, Complementary
  • Proteins
  • Cysteine