Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum

Chem Commun (Camb). 2006 Jan 14:(2):174-6. doi: 10.1039/b510812h. Epub 2005 Nov 21.

Abstract

A crystal structure is reported of the peptide Ac-Ala-Asn-Pro-Asn-Ala-NH2, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I beta-turn, which is stabilized by hydrogen bonding between the CO of Asn2 and the NH of Ala5 as well as between the O(delta) of Asn2 and the NH of Asn4.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Crystallization
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Conformation
  • Oligopeptides / chemistry*
  • Plasmodium falciparum / chemistry*
  • Protozoan Proteins / chemistry*
  • Stereoisomerism

Substances

  • Oligopeptides
  • Protozoan Proteins
  • circumsporozoite protein, Protozoan