Approach to novel functional foods for stress control 3. Establishment of stress-resistant rat model and its mechanism

J Med Invest. 2005 Nov:52 Suppl:244. doi: 10.2152/jmi.52.244.

Abstract

A stress-resistant rat model was introduced. SPORTS (Spontaneously-Running-Tokushima-Shikoku) rats showed significantly shorter time of immobility in the forced swim test compared to control Wister rats. Increase norepinephrine concentration secondary to decreased activity of monoamine oxidase A (MAOA) in hippocampus was observed in this model rats. This model rats are considered to be useful for studying the mechanism of psychological stress.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Food*
  • Hippocampus / chemistry
  • Hippocampus / enzymology
  • Models, Animal*
  • Monoamine Oxidase / analysis
  • Monoamine Oxidase / metabolism
  • Motor Activity / genetics*
  • Norepinephrine / analysis
  • Norepinephrine / metabolism
  • Rats
  • Rats, Mutant Strains
  • Rats, Wistar
  • Stress, Physiological / genetics*
  • Stress, Physiological / metabolism*
  • Stress, Psychological / prevention & control*
  • Swimming
  • Time Factors

Substances

  • Monoamine Oxidase
  • Norepinephrine