Abstract
A stress-resistant rat model was introduced. SPORTS (Spontaneously-Running-Tokushima-Shikoku) rats showed significantly shorter time of immobility in the forced swim test compared to control Wister rats. Increase norepinephrine concentration secondary to decreased activity of monoamine oxidase A (MAOA) in hippocampus was observed in this model rats. This model rats are considered to be useful for studying the mechanism of psychological stress.
MeSH terms
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Animals
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Food*
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Hippocampus / chemistry
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Hippocampus / enzymology
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Models, Animal*
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Monoamine Oxidase / analysis
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Monoamine Oxidase / metabolism
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Motor Activity / genetics*
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Norepinephrine / analysis
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Norepinephrine / metabolism
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Rats
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Rats, Mutant Strains
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Rats, Wistar
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Stress, Physiological / genetics*
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Stress, Physiological / metabolism*
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Stress, Psychological / prevention & control*
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Swimming
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Time Factors
Substances
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Monoamine Oxidase
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Norepinephrine