Abstract
The modulation of antigen receptor signals is important for a productive immune response. The main function of the recently identified members of the signaling lymphocyte activating molecule (SLAM)-related receptors (SRR) is the fine-tuning of immune cell activation. Disruption of SRR function is the cause for severe immune disorders such as X-linked lymphoproliferative syndrome (XLP), where XLP patients carry a mutation in SLAM-associated protein (SAP) (SH2D1A), an important adaptor molecule for the signal transduction of SRR. Recent data also suggest that SRR may play a role in autoimmune diseases and the function of hematopoietic stem and progenitor cells. Here, we review the current understanding of SRR function in different immune cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / immunology
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Glycoproteins / immunology*
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Humans
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Immune System / immunology*
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Immunoglobulins / immunology*
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Intracellular Signaling Peptides and Proteins / immunology*
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Membrane Glycoproteins / immunology
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Receptors, Cell Surface
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Receptors, Immunologic / immunology*
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Signal Transduction / immunology
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Signaling Lymphocytic Activation Molecule Associated Protein
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Signaling Lymphocytic Activation Molecule Family
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Signaling Lymphocytic Activation Molecule Family Member 1
Substances
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Antigens, CD
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CD244 protein, human
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Glycoproteins
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Immunoglobulins
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Intracellular Signaling Peptides and Proteins
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LY9 protein, human
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Membrane Glycoproteins
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Receptors, Cell Surface
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Receptors, Immunologic
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SH2D1A protein, human
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SLAMF7 protein, human
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Signaling Lymphocytic Activation Molecule Associated Protein
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Signaling Lymphocytic Activation Molecule Family
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Signaling Lymphocytic Activation Molecule Family Member 1