Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge

Amanda L Harris; Xiaohong Yang; Alex Hegmans; Lawrence Povirk; John J Ryan; Lloyd Kelland; Nicholas P Farrell

doi:10.1021/ic051390z

Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge

Inorg Chem. 2005 Dec 26;44(26):9598-600. doi: 10.1021/ic051390z.

Authors

Amanda L Harris¹, Xiaohong Yang, Alex Hegmans, Lawrence Povirk, John J Ryan, Lloyd Kelland, Nicholas P Farrell

Affiliation

¹ Chemistry Department, Virginia Commonwealth University, 1001 W. Main Street, Richmond, Virginia 23284-2006, USA.

PMID: 16363817
DOI: 10.1021/ic051390z

Abstract

Charge delocalization (6+ to 8+) in "noncovalent" linear trinuclear platinum complexes produces compounds with cytotoxicity in some cases equivalent to cisplatin. The cellular uptake of a novel 8+ compound is greater than that of neutral cisplatin as well as other multinuclear Pt compounds.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Humans
Molecular Structure
Platinum Compounds / chemical synthesis*
Platinum Compounds / chemistry
Platinum Compounds / toxicity*

Substances

Platinum Compounds

Grants and funding

CA-78754/CA/NCI NIH HHS/United States