Synthesis and antihyperglycemic evaluation of various protoberberine derivatives

Xiaoli Bian; Langchong He; Guangde Yang

doi:10.1016/j.bmcl.2005.11.045

Synthesis and antihyperglycemic evaluation of various protoberberine derivatives

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1380-3. doi: 10.1016/j.bmcl.2005.11.045. Epub 2005 Dec 15.

Authors

Xiaoli Bian¹, Langchong He, Guangde Yang

Affiliation

¹ School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.

PMID: 16359864
DOI: 10.1016/j.bmcl.2005.11.045

Abstract

Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alloxan / pharmacology
Animals
Berberine Alkaloids / chemical synthesis
Berberine Alkaloids / chemistry*
Berberine Alkaloids / pharmacology*
Diabetes Mellitus, Experimental / chemically induced
Diabetes Mellitus, Experimental / drug therapy
Hypoglycemic Agents / chemical synthesis*
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / pharmacology*
Mice
Molecular Structure
Structure-Activity Relationship

Substances

Berberine Alkaloids
Hypoglycemic Agents
protoberberine
Alloxan