Abstract
New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / toxicity
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CHO Cells
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Colchicine / analogs & derivatives*
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Colchicine / chemical synthesis
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Colchicine / pharmacology
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Colchicine / toxicity
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Cricetinae
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Cricetulus
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Dose-Response Relationship, Drug
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Humans
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Inhibitory Concentration 50
Substances
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Antineoplastic Agents
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thiocholchicine
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Colchicine