New synthetic thiocolchicine derivatives as lowtoxic anticancer agents

Arch Pharm (Weinheim). 2005 Dec;338(12):582-9. doi: 10.1002/ardp.200500148.

Abstract

New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / toxicity
  • CHO Cells
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Colchicine / analogs & derivatives*
  • Colchicine / chemical synthesis
  • Colchicine / pharmacology
  • Colchicine / toxicity
  • Cricetinae
  • Cricetulus
  • Dose-Response Relationship, Drug
  • Humans
  • Inhibitory Concentration 50

Substances

  • Antineoplastic Agents
  • thiocholchicine
  • Colchicine