A triterpenoid saponin possessing antileishmanial activity from the leaves of Careya arborea

Phytochemistry. 2006 Jan;67(2):183-90. doi: 10.1016/j.phytochem.2005.10.028. Epub 2005 Dec 15.

Abstract

Bioguided-fractionation of the methanol extract of the leaves of Careya arborea led to isolation of a triterpenoid saponin, designated arborenin, and characterized as 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl-2 alpha,3beta-dihydroxy-taraxast-20-en-28-oic acid (1), together with desacylescin III (2). The structures were determined on the basis of extensive 2D NMR spectroscopic analysis. The saponin showed in vitro antileishmanial activity against Leishmania donovani (strain AG 83).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / isolation & purification
  • Antiprotozoal Agents / pharmacology*
  • Carbohydrate Sequence
  • Lecythidaceae / chemistry*
  • Leishmania donovani / drug effects*
  • Magnetic Resonance Spectroscopy / methods
  • Magnetic Resonance Spectroscopy / standards
  • Molecular Conformation
  • Molecular Sequence Data
  • Parasitic Sensitivity Tests
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry*
  • Reference Standards
  • Saponins / chemistry
  • Saponins / isolation & purification
  • Saponins / pharmacology*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antiprotozoal Agents
  • Plant Extracts
  • Saponins
  • Triterpenes