Abstract
The chemical investigation of the ethanolic extract of the root bark of Onosma hispidum following antibacterial activity directed isolation led to the isolation of 4-hydroxy-3-methoxy cinnamic acid (ferulic acid) and 4-hydroxy-3-methoxy benzoic acid (vanillic acid) which have been reported for the first time in this species. In addition to these compounds, the crude ethanolic extract and methanol fraction exhibited substantial bioactivity against species of corynebacteria, enterococci, staphylococci and streptococci. Ferulic acid was found more bioactive (being relatively more hydrophobic) compared to vanillic acid.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Boraginaceae / chemistry*
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Chromatography, Thin Layer
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Coumaric Acids / chemistry
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Coumaric Acids / isolation & purification*
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Coumaric Acids / pharmacology
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Vanillic Acid / chemistry
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Vanillic Acid / isolation & purification*
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Vanillic Acid / pharmacology
Substances
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Anti-Bacterial Agents
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Coumaric Acids
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ferulic acid
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Vanillic Acid