Two methylene groups in phospholipids distinguish between apoptosis and necrosis for tumor cells

Hideaki Nagami; Koji Nakano; Hideaki Ichihara; Yoko Matsumoto; Ryuichi Ueoka

doi:10.1016/j.bmcl.2005.11.034

Two methylene groups in phospholipids distinguish between apoptosis and necrosis for tumor cells

Bioorg Med Chem Lett. 2006 Feb 15;16(4):782-5. doi: 10.1016/j.bmcl.2005.11.034. Epub 2005 Dec 6.

Authors

Hideaki Nagami¹, Koji Nakano, Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka

Affiliation

¹ Graduate Course of Applied Chemistry, Sojo University, Ikeda, Kumamoto 860-0082, Japan.

PMID: 16337792
DOI: 10.1016/j.bmcl.2005.11.034

Abstract

High inhibitory effects of hybrid liposomes (HL) themselves composed of DMPC/10 mol% C12(EO)23 on the growth of HL-60 cells were obtained without any drug. Induction of apoptosis was obtained by the HL of DMPC/10 mol% C12(EO)23. On the other hand, necrosis was observed for the HL of DLPC/10 mol% C12(EO)23. In the case of DPPC/10 mol% C12(EO)23, neither apoptosis nor necrosis was observed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

1,2-Dipalmitoylphosphatidylcholine / chemistry
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Cell Proliferation / drug effects
Dimyristoylphosphatidylcholine / chemistry
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Liposomes / chemical synthesis
Liposomes / chemistry
Liposomes / pharmacology*
Molecular Structure
Phosphatidylcholines / chemistry
Phospholipids / chemistry*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Liposomes
Phosphatidylcholines
Phospholipids
1,2-dilauroylphosphatidylcholine
1,2-Dipalmitoylphosphatidylcholine
Dimyristoylphosphatidylcholine