Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide

Pediatr Blood Cancer. 2007 Sep;49(3):341-3. doi: 10.1002/pbc.20617.

Abstract

Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cerebellar Neoplasms / drug therapy
  • Child
  • Child, Preschool
  • Cyclophosphamide / administration & dosage
  • Drug Hypersensitivity / etiology*
  • Female
  • Humans
  • Medulloblastoma / drug therapy
  • Mesna / administration & dosage
  • Mesna / adverse effects*
  • Osteosarcoma / drug therapy
  • Protective Agents / administration & dosage
  • Protective Agents / adverse effects*
  • Spinal Neoplasms / drug therapy

Substances

  • Protective Agents
  • Cyclophosphamide
  • Mesna