Dynein motility: four heads are better than two

Curr Biol. 2005 Dec 6;15(23):R970-2. doi: 10.1016/j.cub.2005.11.021.

Abstract

Cytoplasmic dynein is a microtubule-based motor protein that transports membranes in cells. The movement driven by a single dynein molecule in vitro is not as robust as dynein-driven movements in cells. A new study suggests that transport by multiple dyneins is more similar to cellular motions.

Publication types

  • Review

MeSH terms

  • Dynactin Complex
  • Dyneins / metabolism*
  • Kinesins / metabolism
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / metabolism*
  • Models, Molecular*
  • Molecular Motor Proteins / metabolism*
  • Myosins / metabolism
  • Protein Transport / physiology

Substances

  • Dynactin Complex
  • Microtubule-Associated Proteins
  • Molecular Motor Proteins
  • Myosins
  • Dyneins
  • Kinesins