Brucella meningitis and papilledema in a child

Eur J Ophthalmol. 2005 Nov-Dec;15(6):818-20. doi: 10.1177/112067210501500628.

Abstract

Purpose: To report a rare case of Brucella meningitis with papilledema in a child and to discuss the findings of neurobrucellosis in children.

Methods: A 6-year-old girl was admitted with headache, fever, and vomiting for 1 week. Her family reported intake of raw unpasteurized goat's milk in the past. Meningeal signs were strongly positive. Bilateral moderate optic disc edema with flame-shaped hemorrhages was observed.

Results: The diagnosis of Brucella infection was established by positive blood culture for Brucella species, serum agglutination titer of antibodies to Brucella >1:160, and positive CSF culture. After treatment consisting of trimethoprim-sulfamethoxazole, rifampin, and doxycycline, the patient's condition gradually improved. One month later, the papilledema disappeared. One year after presentation, the patient remains free of symptoms.

Conclusions: Brucella meningitis must be ruled out in symptomatic patients reporting ingestion of raw unpasteurized goat's milk. Papilledema is a frequent clinical feature, but irreversible visual impairment is extremely rare.

Publication types

  • Case Reports

MeSH terms

  • Agglutination Tests
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies, Bacterial / blood
  • Brucella / isolation & purification*
  • Brucellosis / diagnosis
  • Brucellosis / drug therapy
  • Brucellosis / microbiology*
  • Child
  • Doxycycline / therapeutic use
  • Drug Therapy, Combination
  • Eye Infections, Bacterial / diagnosis
  • Eye Infections, Bacterial / drug therapy
  • Eye Infections, Bacterial / microbiology*
  • Female
  • Humans
  • Meningitis, Bacterial / diagnosis
  • Meningitis, Bacterial / drug therapy
  • Meningitis, Bacterial / microbiology*
  • Papilledema / diagnosis
  • Papilledema / drug therapy
  • Papilledema / microbiology*
  • Rifampin / therapeutic use
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Antibodies, Bacterial
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Doxycycline
  • Rifampin