Sleeping in? The impact of age and depressive sub-type on hypersomnia

J Affect Disord. 2006 Jan;90(1):73-6. doi: 10.1016/j.jad.2005.10.004. Epub 2005 Dec 2.

Abstract

Background: While early morning wakening is held to be a classic feature of melancholia, we investigate the clinical observation that young patients with melancholia and bipolar depression tend to be more likely to report hypersomnia.

Methods: We examine age-related rates of those two sleep disturbance patterns in a consecutive set of out-patients with differing depressive sub-types assessed over a 20-year period.

Results: Hypersomnia was more likely to be reported than early morning wakening across all age bands by those with non-melancholic depression. Hypersomnia was also more likely than early morning wakening in younger patients with melancholia and bipolar disorder but, with age, early morning wakening became the dominant pattern.

Limitations: The study was retrospective, undertaken in a sample attending a tertiary referral unit and artefactual determinants of the associations were not pursued.

Conclusions: We speculate that hypersomnia may be a non-specific homeostatic coping response to stress and thus to the non-melancholic depressive disorders, but that this pattern is overruled by an early morning wakening pattern in the more biological depressive sub-types as the individual ages, perhaps reflecting a noradrenergic contribution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Bipolar Disorder / epidemiology*
  • Depression / epidemiology*
  • Disorders of Excessive Somnolence / epidemiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Norepinephrine / blood

Substances

  • Norepinephrine