Antimicrobial properties of highly fluorinated silver(I) tris(pyrazolyl)borates

H V Rasika Dias; Keith H Batdorf; Mauro Fianchini; Himashinie V K Diyabalanage; Sean Carnahan; Ryan Mulcahy; Amir Rabiee; Kevin Nelson; Lorraine G van Waasbergen

doi:10.1016/j.jinorgbio.2005.10.003

Antimicrobial properties of highly fluorinated silver(I) tris(pyrazolyl)borates

J Inorg Biochem. 2006 Jan;100(1):158-60. doi: 10.1016/j.jinorgbio.2005.10.003.

Authors

H V Rasika Dias¹, Keith H Batdorf, Mauro Fianchini, Himashinie V K Diyabalanage, Sean Carnahan, Ryan Mulcahy, Amir Rabiee, Kevin Nelson, Lorraine G van Waasbergen

Affiliation

¹ Department of Chemistry and Biochemistry, The University of Texas at Arlington, P.O. Box 19065, Arlington, TX 76019, USA. dias@uta.edu

PMID: 16321442
DOI: 10.1016/j.jinorgbio.2005.10.003

Abstract

Highly fluorinated tris(pyrazolyl)borate ligand [HB(3,5-(CF3)2Pz)3]- has been used in the isolation of air- and light-stable silver complex, [HB(3,5-(CF3)2Pz)3]Ag(OSMe2). It is a monomeric tetrahedral silver complex with an O-bonded dimethylsulfoxide ligand. The silver adduct [HB(3,5-(CF3)2Pz)3]Ag(OSMe2) and the related [HB(3,5-(CF3)2Pz)3] Ag(THF) (where OSMe2 = dimethyl sulfoxide; THF = tetrahydrofuran) show good antibacterial activity, and their antimicrobial efficacy against Staphylococcus aureus is greater than those of AgNO3 and silver sulfadiazine.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Anti-Infective Agents / chemical synthesis
Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology
Borates / chemistry*
Borates / pharmacology
Dimethyl Sulfoxide / chemistry
Furans / chemistry
Microbial Sensitivity Tests
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Organometallic Compounds / pharmacology
Silver / chemistry*
Silver / pharmacology

Substances

Anti-Infective Agents
Borates
Furans
Organometallic Compounds
Silver
tetrahydrofuran
Dimethyl Sulfoxide