Concise synthesis of pochonin A, an HSP90 inhibitor

Org Lett. 2005 Dec 8;7(25):5637-9. doi: 10.1021/ol052263+.

Abstract

[chemical reaction: see text]. An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors
  • Adenosine Triphosphate / antagonists & inhibitors
  • DNA Helicases / antagonists & inhibitors
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors*
  • Lactones / chemical synthesis*
  • Lactones / chemistry
  • Lactones / pharmacology*
  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Macrolides / pharmacology*
  • Molecular Structure
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • HSP90 Heat-Shock Proteins
  • Lactones
  • Macrolides
  • pochonin A
  • Adenosine Triphosphate
  • Adenosine Triphosphatases
  • DNA Helicases
  • monorden