Background: Earlier we showed cardiac isoform of alpha-2 macroglobulin (CA2M) to be an early marker of cardiac hypertrophy.
Design: In this study, we tried to explore the possibility of using this protein as a marker for diagnosis of cardiac diseases.
Methods: A total of 593 samples were analyzed for the presence of CA2M using sandwich enzyme-linked immunosorbent assay.
Results: Samples include various cardiac diseases (230), non-cardiac ailments (263) and controls (100).
Conclusion: Levels of CA2M in cardiac diseases were significantly higher than other sample groups but moderately elevated in leprosy. This protein could be considered for diagnosis of cardiac diseases as a serum marker.