Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: a case report and review of the literature

Liver Transpl. 2005 Dec;11(12):1611-4. doi: 10.1002/lt.20626.

Abstract

Sarcoidosis is a systemic granulomatous disease primarily involving the lungs, lymph nodes, skin, eyes and nervous system; liver involvement is asymptomatic in most cases. However, once the patient develops clinical symptoms liver disease is usually progressive and may necessitate orthotopic liver transplantation. There are a few reports of asymptomatic recurrent sarcoidosis developing within the liver allograft. We report a case of early recurrence of sarcoidosis in the liver allograft diagnosed on biopsy in a patient who presented with severe hypercalcemia, kidney dysfunction, and increase in size of abdominal lymph nodes. The liver chemistry tests were within normal limits. The patient responded well to steroid treatment by normalizing serum calcium and creatinine levels and reducing lymph node size. To date, there has been no report in the literature of symptomatic recurrence of hepatic sarcoidosis following orthotopic liver transplantation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Calcium / blood
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • Humans
  • Hypercalcemia / blood
  • Hypercalcemia / drug therapy
  • Hypercalcemia / etiology*
  • Liver / pathology
  • Liver Diseases / drug therapy
  • Liver Diseases / etiology*
  • Liver Diseases / pathology
  • Liver Transplantation / adverse effects*
  • Liver Transplantation / pathology
  • Magnetic Resonance Imaging
  • Prednisolone / therapeutic use
  • Recurrence
  • Sarcoidosis / drug therapy
  • Sarcoidosis / etiology*
  • Sarcoidosis / pathology

Substances

  • Glucocorticoids
  • Prednisolone
  • Calcium