The mechanism of depression attack was studied from the point of view of TCM theory, literature and clinical practice. It is held that the brain and liver are the key zang- and fu-organs for attack of depression, and it is first put forward that dysfunction of mind and the liver failing in soothing and regulating the circulation of qi are the TCM pathogenesis of this disease. Needling method for regulating mind and soothing the liver is established with the acupoints of The Governor Vessel and The Liver Channel selected mainly.