Chemokines in host-parasite interactions in leishmaniasis

Trends Parasitol. 2006 Jan;22(1):32-40. doi: 10.1016/j.pt.2005.11.010. Epub 2005 Nov 23.

Abstract

Crucial to the defense against leishmaniasis is the ability of the host to mount a cell-mediated immune response capable of controlling and/or eliminating the parasite. Cell recruitment to the site of infection is essential to the development of the host cellular immune response. The process is controlled by chemokines, which are chemotactic cytokines produced by leukocytes and tissue cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokines / chemistry
  • Chemokines / classification
  • Chemokines / immunology*
  • Cytokines / immunology
  • Host-Parasite Interactions / immunology
  • Humans
  • Immunity, Innate / immunology
  • Leishmania / immunology*
  • Leishmania / pathogenicity
  • Leishmaniasis / drug therapy
  • Leishmaniasis / immunology*
  • Leishmaniasis / parasitology*
  • Leishmaniasis, Cutaneous / immunology
  • Leishmaniasis, Cutaneous / parasitology
  • Leishmaniasis, Visceral / immunology
  • Leishmaniasis, Visceral / parasitology
  • Macrophage Activation / immunology
  • Mice
  • Receptors, Chemokine / classification
  • Virulence / immunology

Substances

  • Chemokines
  • Cytokines
  • Receptors, Chemokine