Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines

Xu Hui; Julie Desrivot; Christian Bories; Philippe M Loiseau; Xavier Franck; Reynald Hocquemiller; Bruno Figadère

doi:10.1016/j.bmcl.2005.11.025

Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines

Bioorg Med Chem Lett. 2006 Feb 15;16(4):815-20. doi: 10.1016/j.bmcl.2005.11.025. Epub 2005 Nov 23.

Authors

Xu Hui¹, Julie Desrivot, Christian Bories, Philippe M Loiseau, Xavier Franck, Reynald Hocquemiller, Bruno Figadère

Affiliation

¹ Laboratoire de Pharmacognosie et Groupe Chimiothérapie Antiparasitaire (associé au CNRS-BioCIS) Faculté de Pharmacie, Université de Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France.

PMID: 16309903
DOI: 10.1016/j.bmcl.2005.11.025

Abstract

A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / chemical synthesis*
Antiprotozoal Agents / chemistry
Antiprotozoal Agents / pharmacology*
In Vitro Techniques
Leishmania donovani / drug effects
Molecular Structure
Parasitic Sensitivity Tests
Quinoxalines / chemical synthesis*
Quinoxalines / chemistry
Quinoxalines / pharmacology*
Structure-Activity Relationship
Trichomonas vaginalis / drug effects
Trypanosoma brucei brucei / drug effects

Substances

Antiprotozoal Agents
Quinoxalines