Dichotomins J and K, vasodilator cyclic peptides from Stellaria dichotoma

J Nat Prod. 2005 Nov;68(11):1686-8. doi: 10.1021/np050262k.

Abstract

Two new cyclic peptides, dichotomins J (1) and K (2), have been isolated from the roots of Stellaria dichotoma, and their structures were elucidated by chemical degradation and extensive 2D NMR methods. Dichotomins J (1) and K (2) showed a moderate vasorelaxant effect on rat aorta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / drug effects
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Molecular Structure
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Rats
  • Stellaria / chemistry*
  • Vasodilator Agents / chemistry
  • Vasodilator Agents / isolation & purification*
  • Vasodilator Agents / pharmacology

Substances

  • Drugs, Chinese Herbal
  • Peptides, Cyclic
  • Vasodilator Agents
  • dichotomin J
  • dichotomin K