Abstract
Two new cyclic peptides, dichotomins J (1) and K (2), have been isolated from the roots of Stellaria dichotoma, and their structures were elucidated by chemical degradation and extensive 2D NMR methods. Dichotomins J (1) and K (2) showed a moderate vasorelaxant effect on rat aorta.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta / drug effects
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Molecular Structure
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Rats
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Stellaria / chemistry*
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Vasodilator Agents / chemistry
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Vasodilator Agents / isolation & purification*
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Vasodilator Agents / pharmacology
Substances
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Drugs, Chinese Herbal
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Peptides, Cyclic
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Vasodilator Agents
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dichotomin J
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dichotomin K