Abstract
Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.
MeSH terms
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Alkaloids / chemistry*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Aspergillus fumigatus / drug effects
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Candida albicans / drug effects
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Carbolines
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Cryptococcus neoformans / drug effects
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Drug Evaluation, Preclinical
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Indole Alkaloids
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Indoles* / chemical synthesis
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Indoles* / chemistry
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Indoles* / isolation & purification
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Indoles* / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Naphthyridines* / chemical synthesis
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Naphthyridines* / chemistry
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Naphthyridines* / isolation & purification
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Naphthyridines* / pharmacology
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Plants, Medicinal / chemistry*
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Saccharomyces cerevisiae / drug effects
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Structure-Activity Relationship
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Trichophyton / drug effects
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Zanthoxylum / chemistry*
Substances
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Alkaloids
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Antifungal Agents
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Carbolines
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Indole Alkaloids
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Indoles
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Naphthyridines
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canthin-6-one