Are vanadium compounds drugable? Structures and effects of antidiabetic vanadium compounds: a critical review

Mini Rev Med Chem. 2005 Nov;5(11):995-1008. doi: 10.2174/138955705774575264.

Abstract

Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chelating Agents / chemistry
  • Humans
  • Hypoglycemic Agents* / chemistry
  • Hypoglycemic Agents* / pharmacokinetics
  • Hypoglycemic Agents* / therapeutic use
  • Hypoglycemic Agents* / toxicity
  • Models, Molecular
  • Molecular Sequence Data
  • Vanadium Compounds / chemistry
  • Vanadium Compounds / pharmacokinetics
  • Vanadium Compounds / pharmacology*
  • Vanadium Compounds / therapeutic use
  • Vanadium Compounds / toxicity

Substances

  • Chelating Agents
  • Hypoglycemic Agents
  • Vanadium Compounds