Cooperative type of platelet hypersensitivity to ADP

E Yu Shabanova; I V Mindukshev; E A Malakhovskaya; E V Vivulanets; N N Petrishchev; A I Krivchenko

doi:10.1007/s10517-005-0467-z

Cooperative type of platelet hypersensitivity to ADP

Bull Exp Biol Med. 2005 Sep;140(3):282-4. doi: 10.1007/s10517-005-0467-z.

Authors

E Yu Shabanova¹, I V Mindukshev, E A Malakhovskaya, E V Vivulanets, N N Petrishchev, A I Krivchenko

Affiliation

¹ Laboratory for Physiology of Respiration, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg. helen_shabanova@mail.ru

PMID: 16307036
DOI: 10.1007/s10517-005-0467-z

Abstract

We found that gestosis is associated with platelet hypersensitivity to ADP. Cell P2X1 receptors exhibited a positive cooperative response to ADP (EC(50)=10.88+/-3.70 nM, Hill constant n=2.59+/-0.50 rel. units). Cooperative binding of ADP to platelet P2X1 receptors was also observed during incubation of cells from pregnant women with isosorbide dinitrate.

MeSH terms

Adenosine Diphosphate / pharmacology*
Female
Humans
Platelet Aggregation / drug effects*
Pre-Eclampsia / blood*
Pregnancy
Receptors, Purinergic P2 / physiology
Receptors, Purinergic P2X

Substances

Receptors, Purinergic P2
Receptors, Purinergic P2X
Adenosine Diphosphate