Allogeneic peripheral blood stem cell transplant (PBSCT) using anti-IL2 receptor antibody Daclizumab for the prevention of acute graft versus host disease in steroid refractory Diamond Blackfan anaemia: a case report

J Pak Med Assoc. 2005 Oct;55(10):454-5.

Abstract

The case report of a 2 year old boy with steroid refractory DBA, treated with allogeneic PBSCT from an HLA matched sibling is presented. Anti-IL2 receptor antibody Daclizumab was used as a prophylaxis for graft versus host disease (GvHD). Complete recovery without any evidence of GvHD ensued.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anemia, Diamond-Blackfan / drug therapy
  • Anemia, Diamond-Blackfan / surgery*
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Daclizumab
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use*
  • Graft vs Host Disease / blood
  • Graft vs Host Disease / prevention & control*
  • Humans
  • Immunoglobulin G / therapeutic use*
  • Immunosuppressive Agents / therapeutic use*
  • Infant
  • Male
  • Peripheral Blood Stem Cell Transplantation*
  • Receptors, Interleukin-2 / antagonists & inhibitors*
  • Receptors, Interleukin-2 / blood

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Glucocorticoids
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Receptors, Interleukin-2
  • Daclizumab