We studied the prevalence of musculoskeletal conditions in a rural Oregon primary care practice and the self-assessed musculoskeletal knowledge and skills of primary physicians practicing in the area. We recorded how many musculoskeletal complaints were evaluated and treated in a primary care physician's office between April 1 and April 30, 2002. In addition, to all primary care physicians in the surrounding county, we distributed a self-administered questionnaire assessing physician confidence regarding common musculoskeletal conditions and procedures. Prevalence of musculoskeletal conditions for the month was 17.5% (48/274 office visits). Questionnaire results indicated that local physicians felt relatively uncomfortable with common musculoskeletal conditions (mean confidence scores on a 10-point Likert scale: 4.2, musculoskeletal conditions; 9.0, nonmusculoskeletal medical conditions). These findings suggest a disparity between rural primary care physicians' self-assessed musculoskeletal knowledge and skill and the levels they require for their practice.