Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

Vandana Srivastava; Arvind S Negi; J K Kumar; Uzma Faridi; Brijesh S Sisodia; M P Darokar; Suaib Luqman; S P S Khanuja

doi:10.1016/j.bmcl.2005.10.105

Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

Bioorg Med Chem Lett. 2006 Feb 15;16(4):911-4. doi: 10.1016/j.bmcl.2005.10.105. Epub 2005 Nov 15.

Authors

Vandana Srivastava¹, Arvind S Negi, J K Kumar, Uzma Faridi, Brijesh S Sisodia, M P Darokar, Suaib Luqman, S P S Khanuja

Affiliation

¹ Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, Kukrail Road, Lucknow 226 015, India.

PMID: 16297622
DOI: 10.1016/j.bmcl.2005.10.105

Abstract

3',4',5'-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The product 8 showed significant anticancer activity against human cancer cell lines COLO320DM (colon), CaCO2 (colon) and WRL68 (liver) at 0.7, 0.65 and 0.50 microg/ml concentrations, respectively, in the in vitro MTT assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
Furans / chemical synthesis*
Furans / chemistry
Furans / pharmacology*
Humans
In Vitro Techniques
Molecular Structure
Structure-Activity Relationship

Substances

1-(3',4',5'-trimethoxy)phenylnaphtho(2,1b)furan
Antineoplastic Agents
Furans