1-Aryl-5-benzylsulfanyltetrazoles, a new group of antimycobacterial compounds against potentially pathogenic strains

K Waisser; J Adamec; R Dolezal; J Kaustová

doi:10.1007/BF02931565

1-Aryl-5-benzylsulfanyltetrazoles, a new group of antimycobacterial compounds against potentially pathogenic strains

Folia Microbiol (Praha). 2005;50(3):195-7. doi: 10.1007/BF02931565.

Authors

K Waisser¹, J Adamec, R Dolezal, J Kaustová

Affiliation

¹ Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czechia. waisser@faf.cuni.cz

PMID: 16295656
DOI: 10.1007/BF02931565

Abstract

A set of 21 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was evaluated for in vitro antimycobacterial activity against Mycobacterium avium and two strains of M. kansasii. We tried to use the Hansch approach, the Free-Wilson approach and their combination for structure-activity correlation but the calculations were statistically insignificant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Humans
In Vitro Techniques
Microbial Sensitivity Tests
Mycobacterium avium / drug effects*
Mycobacterium avium / pathogenicity
Mycobacterium kansasii / drug effects*
Mycobacterium kansasii / pathogenicity
Structure-Activity Relationship
Tetrazoles / chemistry
Tetrazoles / pharmacology*

Substances

Anti-Bacterial Agents
Tetrazoles