Expression of TAp73 and DeltaNp73 isoform transcripts in thyroid tumours

Eur J Surg Oncol. 2006 Mar;32(2):228-30. doi: 10.1016/j.ejso.2005.09.014. Epub 2005 Nov 14.

Abstract

Aim: This study was aimed to determine p73 status in thyroid tumours.

Methods: Differential expression of the TAp73, DeltaTAp73 transcripts was measured in a panel of 60 thyroid malignancies by quantitative RT-PCR.

Results: By comparison to normal thyroid tissue surrounding the tumours, we observed significant downregulation of TP73 transcripts in adenomas and in differentiated carcinomas. Correlations were found in normal tissue specimens between the expression of TAp73 and DeltaNp73 transcripts and that of p53, p14ARF p16INK4a, but these correlations were lost in carcinomas (PTC or FTC).

Conclusions: We have found significant variations of TAp73, DeltaNp73, p53, p14ARF p16INK4a, expressions and correlations between the expressions of those different genes in thyroid cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma, Follicular / chemistry*
  • Adenoma, Oxyphilic / chemistry*
  • Carcinoma, Papillary / chemistry*
  • Case-Control Studies
  • Cyclin-Dependent Kinase Inhibitor p16 / analysis
  • DNA-Binding Proteins / analysis*
  • DNA-Binding Proteins / genetics
  • France
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Nuclear Proteins / analysis*
  • Nuclear Proteins / genetics
  • Protein Isoforms
  • RNA, Messenger / genetics
  • Thyroid Neoplasms / chemistry*
  • Transcription, Genetic
  • Tumor Suppressor Protein p14ARF / analysis
  • Tumor Suppressor Protein p53 / analysis
  • Tumor Suppressor Proteins / analysis*
  • Tumor Suppressor Proteins / genetics

Substances

  • Cyclin-Dependent Kinase Inhibitor p16
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Protein Isoforms
  • RNA, Messenger
  • Tumor Suppressor Protein p14ARF
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins