Abstract
Bioassay directed-fractionation led to isolation of 12 compounds from the roots of Bursera tonkinensis Guillaum (Burseraceae), including burselignan, bursephenylpropane, and burseneolignan. Of the 12 compounds, only 4'-demethyldesoxypodophyllotoxin exhibited significant cytotoxic activities against KB, Col2 and LNCaP cell lines.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bursera / chemistry*
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Drug Screening Assays, Antitumor
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Humans
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Lignans / chemistry
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Lignans / isolation & purification
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Magnetic Resonance Spectroscopy
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Male
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Molecular Structure
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Plant Roots / chemistry*
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Podophyllotoxin / analogs & derivatives
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Podophyllotoxin / chemistry
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Podophyllotoxin / pharmacology
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Tumor Cells, Cultured
Substances
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4'-demethyldesoxypodophyllotoxin
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Antineoplastic Agents, Phytogenic
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Lignans
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Podophyllotoxin