Inhibition of EGFR signaling: all mutations are not created equal

PLoS Med. 2005 Nov;2(11):e377. doi: 10.1371/journal.pmed.0020377. Epub 2005 Nov 29.

Abstract

Gazdar and Minna discuss the context and implications of a research article that examines the transformation potential and response to inhibitors of specific EGFR mutations found in lung cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ErbB Receptors / genetics*
  • ErbB Receptors / physiology
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / physiopathology
  • Protein-Tyrosine Kinases / genetics*
  • Protein-Tyrosine Kinases / metabolism
  • Signal Transduction*

Substances

  • ErbB Receptors
  • Protein-Tyrosine Kinases