Abstract
Hetero-bis-metalated 1,3-butadiene is employed in the lynchpin coupling of synthetic fragments of the side chain of the antitumor agent, lucilactaene. Sequential Stille and Suzuki-Miyaura couplings interpolate this unique boron/tin diene into the pentaene chain. The total synthesis of lucilactaene was accomplished efficiently, in just eight linear steps.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Cell Cycle / drug effects*
-
Cells / chemistry
-
Cells / metabolism*
-
Furans / chemical synthesis*
-
Furans / chemistry
-
Furans / pharmacology*
-
Molecular Structure
-
Pyrroles / chemical synthesis*
-
Pyrroles / chemistry
-
Pyrroles / pharmacology*
-
Tumor Suppressor Protein p53 / deficiency*
Substances
-
Furans
-
Pyrroles
-
Tumor Suppressor Protein p53
-
lucilactaene