Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III)

Bioconjug Chem. 2005 Nov-Dec;16(6):1597-609. doi: 10.1021/bc0501808.

Abstract

Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and (1)H and (13)C NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrates / chemistry*
  • Gallium / chemistry*
  • Indium / chemistry*
  • Ligands
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Pyridones / chemistry
  • Radiopharmaceuticals / chemical synthesis*
  • Spectrum Analysis

Substances

  • Carbohydrates
  • Ligands
  • Organometallic Compounds
  • Pyridones
  • Radiopharmaceuticals
  • Indium
  • Gallium